The role of Normal flora in emergence and spread of antimicrobial resistance

Antibiotic resistance is increasing dramatically in all parts of the world. New resistance factors are responsible to spread antibiotic resistance microorganism over the world and makes difficult to treat common infectious diseases. While antibiotics become less effective most infection disease becoming life treating. The irresponsible use of antibiotics in several dedicates is associated with emergence of antibiotic resistance in micro-organisms, destroying the normal flora gives the chance for multiplication of infections and the other microbes with the resistant genes. The antibiotics have lethal effect on normal flora and decrease the colonization, thus microorganisms are possess resistance genes can grow and spread among the normal flora and pathogens, and this rise the number of resistance micro-organism. In recent years due to the decline in the approval of new drugs, abuse and misuse of antibiotics , especially in hospitals, and community, and uses as a growth factor in live stocks, creating a crisis of antibiotic resistance. Normal flora is one of the most agents which are responsible for the transportation of resistance genes by with spread between the other Normal flora, and pathogenic bacteria in hospital, community and in animal, and it is more responsible for hospital acquired resistance infections. The Resistance emerges by changing the environmental conditions, Thus normal flora is the resource of genes which has antibiotic resistance characteristic and most dependable the increase of antimicrobial resistance.