Systematic Review of the Efficacy of Metformin in Diabetes Mellitus Patients – Meta Analysis

Diabetes Mellitus (DM) is a progressive and non-communicable disease. Around 9 percent of the people suffer due to this disease in all over the world. There are several interventions available to treat the disease; one among them is Metformin. It is the choice of most of the clinical practitioners for treating DM. In this article, systematic review methodology has been adopted to assess the effect of the intervention ‘Metformin’. Systematic review finds solution for a research question through ‘n’ number of research articles which are already done by others. Several related articles are extracted from the internet and they are validated (whether good article or not) by five point Jadad scale. Good quality articles’ data are further analysed through Meta analysis. Thus, 5 articles are taken for the systematic review. Risk ratios are calculated in each selected articles and they are compared with one another. Random effect model has been applied to accommodate variation between studies in Meta analysis. Meta Analysis such as forest plot and funnel plot are used to validate the efficacy of the Metformin in DM patients. R-programming language is utilized to carry out the work. The results are displayed in tables and figures.