Suzuki Coupling Reaction General Mechanism and Its Use in Organic Synthesis

January-2016 | Published Online: 10 January 2016    PDF ( 151 KB )
Author(s)
Dr. Rajesh P. Sathwara 1

1Asso. Prof., Department of Chemistry, R.G. Shah Science College, Vasana, Ahmedabad

Abstract

A Suzuki reaction involves the cross-coupling of an organo- boron reagent with an organohalide, catalyzed by palladium.[1] Suzuki cross coupling reaction is very famous reaction in the field of chemistry. It is a very effective method for making carbon –carbon bonds. It has been extensively utilized in the synthesis of many carbon molecules including the most complex ones. It also
find application in the synthesis of compounds of like Boscalid, OTBN, Crizotinib, Ruxolitinib, Vemurafenib, Arbiraterone
acetate etc which have been synthesized using the same reaction along with some other organic compounds. The present review
article emphasis on carbon-carbon bond formation via cross coupling reaction, mechanism, experimental procedure, applications
in a pharmaceutical industries and advantages of Suzuki reaction.

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