Synthesis Involving Metals

Vol-1| Issue-3 | March 2016 | Published Online: 10 March 2016    PDF ( 274 KB )
Dr. Rajesh P. Sathwara 1

1Asso. Prof., Department of Chemistry, R.G. Shah Science College, Vasana, Ahmedabad, Gujarat (India)


A wide spectrum of synthetic methods have been used towards the synthesis of isocoumarins and 3,4-dihydroisocoumarins91. A number of newmethods 92-102 are being developed and reported each year. Some of these methods provide the isocoumarins directly whereas others lead to the 3,4- dihydroisocoumarins. Some of the most important, high yield methods applicable to the synthesis of a large number of these compounds are mentioned below. Literature reveals that isocoumarins and 3,4-dihydroisocoumarins have been extensively prepared by such methods, involving metallation at specificposition like lithiation, silylation and thallation etc.

Lithiation Reaction, thallation, dihydroisocoumarins
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