Synthesis and characterization of Linear PNC-28 Peptide, a p53-derived peptide
| Vol-4 | Issue-03 | March 2019 | Published Online: 13 March 2019 PDF ( 459 KB ) | ||
| Author(s) | ||
| Deepshikha 1; Pillai V.N. Rajasekharan 2 | ||
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1Research Scholar ,Department of Chemistry, Mewar University, Gangrar, Chittorgarh, Rajasthan, India, 312901 (India) 2Professor, Department of Chemistry, Mewar University, Gangrar, Chittorgarh, Rajasthan, India, 312901 (India) |
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| Abstract | ||
Linear PNC-28 Peptide (ETFSDLWKLL) was synthesized by using the solid Phase Peptide Synthesis method. The resin used in this method, as solid support was Wang resin, and it's loading capacity was 1.5 mmol/g. The chemical formula of PNC-28 Peptide is C60H90N12O17. The molecular weight of PNC-28 is 1251.5 g/mol and its sequence composition in percentage is: acidic=20%, basic=10%, neutral=20%, hydrophobic=50%. Nature of PNC-28 peptide is anticancer which treats pancreatic cancer and its origin is Antennapedia. The successful synthesis of PNC-28 Peptide is confirmed by LC-MS FTIR, 1HNMR and CD. |
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| Keywords | ||
| LC-MS, CD, FTIR, 1HNMR. | ||
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