Selection of excipients for cefdinir floating tablets through drug excipient compatibility testing

Cefdinir is an expanded-spectrum, oral, third-generation cephalosporin antimicrobial agent active against Gram-positive and Gram-negative bacteria. It is used in the treatment of acute chronic bronchitis, rhino sinusitis, and pharyngitis and uncomplicated skin and skin structure infections in adults and adolescents, it is indicated for acute otitis media, acute sinusitis, and community-acquired pneumonia. Preformulationis the first step in the rational formulation of an active pharmaceutical ingredient (API). For any formulation interactions studies are very important. When there was no interaction between the choosen drug- excipient orexcipient-excipient then the formulation will be a appropriate one. The selection of suitable study method toevaluate the interaction between the drug and the excipients is a prime most achievement in the pre-formulation study. Recently the thermal analytical techniques is applied to study the interaction study. The objective of thestudy was to study the compatibility of cefdinir drug substance with the excipients employed in the formulation of cefdin floating tablets. Based on the FTIR results cefdinir was found to be compatible with excipients Eudragit, Hydroxy propyl methyl cellulose and gum karaya.