Nicotinic acid, its mechanism of action and pharmacological effects

Vol-6 | Issue-05 | May-2021 | Published Online: 15 May 2021    PDF ( 495 KB )
DOI: https://doi.org/10.31305/rrijm.2021.v06.i05.007
Author(s)
Sanjay Murthy 1; SupriyaThakur 2; Ajit Kumar 3; Sheetal Gupta 4

1Department of Pharmacy Practice, N.E.T Pharmacy College, Karnataka

2Department of Pharmaceutics, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai

3Department of Pharmacy Practice, N.E.T Pharmacy College, Karnataka

4Department of Pharmaceutics, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai

Abstract

Nicotinic acid has a great ability to change the plasma levels of various lipids and lipoproteins. Its ability to increase the plasma concentration of HDL lipoprotein cholesterol has created interest in researchers regarding pharmacological potent of nicotinic acid. Along with great pharmacological benefits, nicotinic also encounters some side effects that are not pleasant especially strong cutaneous vasodilation called flushing. Based on the insights in to the mechanism of action of nicotinic acid new strategies are currently being developed to maximize the potential of drug. In this paper pharmacokinetic, administration, contradictions, adverse effects, monitoring, toxicity are reviewed for nicotinic acid.

Keywords
nicotinic acid, flushing, vitamin B, HDL lipoprotein, nicotinamide
Statistics
Article View: 703