Insilico insights in the Functional characterizationof Calreticulin Protein

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding protein in the lumen of the Endoplasmic reticulum. It is a small size protein. It is seen in vertebrates, invertebrates, and higher plants. It assists in protein folding and acts as Ca2+ buffer inside sarcomeres and outside the Endoplasmic Reticulum in many functional and pathological responses. It is remarked that Calreticulin over-expression or its absence is associated with pathological conditions, such as cancer progression. An insilico attempt has been made to study the functional aspects of Calreticulin protein. Various online Bioinformatics tools were used to characterize and predict the physicochemical properties and protein-protein interactions of Calreticulin protein.