Insilico Evolutionary studies of the Calreticulin protein in selected organisms

Calreticulin has been implicated in the regulation of a variety of cellular functions. Much of the information of Calreticulin is pertaining to its structure and functions but the reason for its conservation during evolution remain obscure.
It has been postulated that the calreticulin protein and the gene are not found in yeast, suggesting that the protein must have emerged later during evolution. There is a considerable amino acid sequence similarity between calreticulin and calnexin, an integral ER membrane chaperone that is present in yeast. In the present study an insilico attempt has been made to study the evolutionary aspects of Calreticulin protein in selected organisms and a few model systems like E coli and Arabidopsis thaliana by using different online computational tools to analyze the conserved regions, domains, and the evolutionary relatedness in the selected organisms.