Evaluation of Impact of Ethanol and Water Extract of Seeds of Tragia involucrata Linn. on the Urine parameters of Albino rats

Plant materials continue to play an important role in the maintenance of human health since antiquity. Over 80% of all chemical drugs originated from natural plant source. Several plants are now being used in part or as a whole to treat many diseases. One such plant is Tragia involucrata, which is a common twining annual plant,grows all over India, specially growing as a weed in cultivated field and open degraded sites. The present investigation mainly aims to discuss the impact of ethanol and water extract of seeds of Tragia involucrata Linn. on the urine parameters of Albino rats. When the animals were treated with ethanol and water extract of the leaves of Tragia involucrata Linn. and fresh urine sample collected from individual rat for 12 hours on 29th /30th day and 59th/60th day . After collecting urine sample, commercial urine analysis strip were used to analyze glucose, bilirubin, ketone, specific gravity, pH and protein. There were no significant changes observed in the mid term (30 day) and end term (60 day) studies. However in case of protein a significant (p<0.05) increase in the end term study at 1000 mg/kg was observed. After gross examination of the urine sample in which changes were seen did not show any detectable abnormalities. The result suggests ethanol and water extract of seeds of Tragia involucrata Linn. is safe when administered orally and it is safe to use as powder, paste and decoction for medicinal purpose.