Protective Role of Ginger (Zingiber officinale) Against Toxicity of Paraquat on Liver of Mus Musculus

Paraquat (PQ) is the leading pesticide used to prevent weeds in agricultural areas. PQ is widely used in 130 countries, including Turkey. PQ (1,1-dimethyl 4,4'-bipiridillium) is a non selective contact herbicide, the contact surface being the leaves of the weed. The acute lethal dose (LD) value of the active ingredient when applied orally is 150 mg kg-1 for rats, 70 mg kg-1 for mice, 25-50 mg kg-1 for dogs, and 262 mg kg-1 for chickens. Paraquat has been shown to be highly toxic by the inhalation route and has been placed in toxicity category (the highest of four levels) for acute inhalation effects. Current study was framed to observe toxicological effect of paraquat (Herbicide) on biochemical and histopathological parameters like Acid phosphatase (ACP), Alkaline phosphatase (ALP), GOT, GPT, Protein and Creatinine of male mice (Mus musculus) and protective role of Ginger (Zingiber officinale) against paraquat toxicity. Our investigations revealed that ginger extract performed a protective role against damage in the liver of mice caused by paraquat. Antioxidant effect of ginger showed improvement in the liver cells, affected by paraquat.